Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
RatBurnContact / flameSprague-DawleyMalen = 160 male Sprague-Dawley rats randomised across burn-blast i…
Model: Combined burn and blast injury producing acute lung injury, assessed from 0 h to 7 days post-injury
Sivelestat reduced bronchoalveolar lavage neutrophil elastase activity and ameliorated the fall in PaO2 and the rises in lavage protein, pulmonary myeloperoxidase activity, wet/dry ratio and serum TNF-alpha and IL-8 seen after burn-blast combined injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.