Immunoglobulin G (IgG) attenuates neuroinflammation and improves neurobehavioral recovery after cervical spinal cord injury.
Model: Cervical clip-compression spinal cord injury: C7-T2 laminectomy then extradural application of a 35 g modified aneurysm clip at C7-T1 for 60 s to produce moderate to severe injury; sham animals received laminectomy without cord compression; all animals received buprenorphine 0.05 mg/kg and 5 mL saline immediately and every 12 h for 3 days
A single 0.4 g/kg intravenous IgG bolus 15 min after cervical clip-compression injury reduced IL-1beta, IL-6 and MCP-1 at 4 h and myeloperoxidase activity, neutrophil counts and matrix metalloproteinase-9 at 24 h, and was associated with less scarring and cavitation, greater tissue preservation, be…
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