Naringenin and quercetin reverse the effect of hypobaric hypoxia and elicit neuroprotective response in the murine model.
MouseOtherMaleOral10 mg/kg eachGiven before every hypoxic exposure
Model: Hypobaric hypoxia exposure in an altitude chamber causing brain injury
Naringenin and quercetin each reduced HIF-1alpha, VEGF, active caspase 3 and ubiquitin levels and ameliorated hypoxia-induced brain dysfunction and behavioural impairment.
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