Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat.
RatTBIFluid percussionSprague-DawleyMaleIntraperitoneal20 mg/kgBeginning 30 min after fluid percussion injury
Model: Single moderate midline fluid percussion injury (1.9-2.0 atm)
Injury produced concomitant classical activation and acquired deactivation microglial phenotypes with raised MHC I, MHC II, TSPO, CD45 and TGF-beta1 at 7 days, and daily ibuprofen significantly reduced expression of these genes.
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