Low tidal volume protects pulmonary vasomotor function from second-hit injury in acute lung injury rats.
RatEndotoxin/LPSSprague-Dawleyn = n=6 per group, 30 rats in 5 groupsMechanical ventilation via tracheotomyTidal volume 6 mL/kg (low), compared with 12 mL/kg (convent…Ventilation began 1 h after lipopolysaccharide injection
Model: Indirect acute lung injury induced by intravenous lipopolysaccharide (E. coli O111:B4) 6 mg/kg via the femoral vein
Compared with 12 mL/kg, 6 mL/kg ventilation reduced endothelin-1 (113.79 versus 152.52 pg/mL) and TNF-alpha (3305 versus 4144 pg/mL), increased eNOS expression, and improved acetylcholine-induced vasodilatation by about 30%.
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