Mesenchymal stem cells increase collagen infiltration and improve wound healing response to porous titanium percutaneous implants.
RatWoundLewisMalen = 25 rats (3, 6, 6, 5 and 5 at 0, 3, 7, 28 and 56 days), each…Local seeding onto the implant surface before implantation6x10^6 cells seeded onto the implantCells seeded before implantation, with transplantation within 4 to 6 h of seedi…
Model: Subdermal implantation of a porous titanium percutaneous implant on the dorsum, creating a skin wound
Collagen infiltrating the porous coating was significantly greater with treated implants at 3 and 28 days, with earlier influx and resolution of inflammatory infiltrate. Vascularisation increased over time in both groups without a significant difference, and epidermal downgrowth was minimal in all…
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