Low-level laser therapy and sodium diclofenac in acute inflammatory response induced by skeletal muscle trauma: effects in muscle morphology and mRNA gene expression of inflammatory markers.

PMID 22937980 ↗2012Reported benefit

Low-level laser therapy and sodium diclofenac in acute inflammatory response induced by skeletal muscle trauma: effects in muscle morphology and mRNA gene expression of inflammatory markers.

RatCrushLimb / muscle crushWistarMaleTranscutaneous laser irradiation, or topical application for diclofenac810 nm continuous, 100 mW, 3.57 W/cm2, 1, 3 or 9 J delivere…1 h after trauma

Model: Single controlled contusion trauma to the tibialis anterior muscle

All laser doses improved muscle morphology and reduced COX-2 at all time points versus injury (p<0.05) and versus diclofenac at 24 h, and reduced TNF-alpha versus both injury and diclofenac at all time points, with 9 J giving the best results.

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Low-level laser therapy and sodium diclofenac in acute inflammatory response induced by skeletal muscle trauma: effects in muscle morphology and mRNA gene expression of inflammatory markers.

Evidence by therapy association

Low-level laser therapy and sodium diclofenac in acute inflammatory response induced by skeletal muscle trauma: effects in muscle morphology and mRNA gene expression of inflammatory markers.