THERAPY DOSSIER · th-3bc85d0e5769

Low-level laser therapy (810 nm) compared with topical sodium diclofenac

Device · Device (low-level laser therapy); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Device (low-level laser therapy); not a ChEMBL entity
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06370910 ↗Injury indicationNAcompleted

Low-Level Laser Therapy vs Cryotherapy in Postpartum Perineal Pain

Episiotomy · Laceration

Enrolment: 56 · Results not recorded

NCT05753540 ↗NAcompleted

MLS Laser Therapy in Patients With Chronic Nonspecific Neck Pain

Chronic Neck Pain

Enrolment: 47 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22937980 ↗2012Reported benefit

Low-level laser therapy and sodium diclofenac in acute inflammatory response induced by skeletal muscle trauma: effects in muscle morphology and mRNA gene expression of inflammatory markers.

RatCrushLimb / muscle crushWistarMaleTranscutaneous laser irradiation, or topical application for diclofenac810 nm continuous, 100 mW, 3.57 W/cm2, 1, 3 or 9 J delivere…1 h after trauma

Model: Single controlled contusion trauma to the tibialis anterior muscle

All laser doses improved muscle morphology and reduced COX-2 at all time points versus injury (p<0.05) and versus diclofenac at 24 h, and reduced TNF-alpha versus both injury and diclofenac at all time points, with 9 J giving the best results.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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