Neuroprotection by manganese superoxide dismutase (MnSOD) mimics: antioxidant effect and oxidative stress regulation in acute experimental stroke.

Neuroprotection by manganese superoxide dismutase (MnSOD) mimics: antioxidant effect and oxidative stress regulation in acute experimental stroke.

Model: Middle cerebral artery occlusion ischaemic stroke

MnTm4PyP pretreatment increased neuronal viability and eliminated intracellular superoxide in vitro, and in vivo reduced infarct volume, improved neurological function and alleviated oxidative stress and apoptosis.

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