THERAPY DOSSIER · th-67370fc1adc5

MnTm4PyP (manganese superoxide dismutase mimic)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03689712 ↗PHASE3completed

ROMAN: Reduction in Oral Mucositis With Avasopasem Manganese (GC4419), Phase 3 in Head and Neck Cancer

Oral Mucositis

Enrolment: 455 · Results not recorded

NCT02457858 ↗PHASE1completed

Manganese Porphyrin MnTE-2-PyP (BMX-010) Preservation of Islet Cell Mass for Clinical Islet Transplantation

Type 1 Diabetes

Enrolment: 5 · Results not recorded

NCT03096756 ↗PHASE1completed

Single Ascending Dose Study of Oral SOD Mimetic GC4702 vs IV GC4419 in Healthy Volunteers

Healthy Volunteer

Enrolment: 48 · Results not recorded

NCT03762031 ↗PHASE1completed

Single Dose Escalation of IV SOD Mimetic GC4711 in Healthy Volunteers

Healthy

Enrolment: 70 · Results not recorded

NCT03099824 ↗PHASE1completed

Formulations of Oral SOD Mimetic GC4711 vs IV GC4419 or GC4711 in Healthy Volunteers

Healthy Volunteers

Enrolment: 56 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22934841 ↗2012Reported benefit

Neuroprotection by manganese superoxide dismutase (MnSOD) mimics: antioxidant effect and oxidative stress regulation in acute experimental stroke.

MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6MaleIntravenous30 min before surgery

Model: Middle cerebral artery occlusion ischaemic stroke

MnTm4PyP pretreatment increased neuronal viability and eliminated intracellular superoxide in vitro, and in vivo reduced infarct volume, improved neurological function and alleviated oxidative stress and apoptosis.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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