Ultraviolet C light for Acinetobacter baumannii wound infections in mice: potential use for battlefield wound decontamination?
MouseBurnContact / flameBALB/cFemalen = Burn model: 21 mice randomised to UVC-treated (n = 12) and…Topical illumination of the wound surface3.24 J/cm2 (20 min illumination) for skin abrasion; 2.59 J/…30 minutes after bacterial inoculation of the wound
Model: Partial-thickness dorsal skin abrasion and full-thickness burn (preheated brass block at approximately 95 degrees C for 7 s), each inoculated with a multidrug-resistant Acinetobacter baumannii clinical isolate carrying the luxCDABE operon
UVC reduced bacterial burden in treated wounds by approximately 10-fold compared with untreated infected controls (p = 0.004 abrasion, p = 0.019 burn). DNA lesions were induced in mouse skin immediately after 3.24 J/cm2 but were extensively repaired within 72 h.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.