THERAPY DOSSIER · th-88b1e10a8394

Ultraviolet C light, irradiance 2.7 mW/cm2

Device · Germicidal short-wavelength ultraviolet radiation; physical modality, no ChEMBL entity. Registered human UV-C studies relate to skin exposure and environmental disinfection rather than direct wound therapy.

Device Suggest a correction

Evidence & regulatory context

Mechanism: Germicidal short-wavelength ultraviolet radiation; physical modality, no ChEMBL entity. Registered human UV-C studies relate to skin exposure and environmental disinfection rather than direct wound therapy.
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: UV-C; Ultraviolet C; UVC light
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05313555 ↗NAterminated

The Effect of Violet Device Dosed UV-C Exposure on Healthy Hand Skin

Healthy Volunteers

Enrolment: 23 · Results not recorded

NCT02605499 ↗NAcompleted

Ultra Violet-C Light Evaluation as an Adjunct to Removing Multi-Drug Resistant Organisms (UVCLEAR-MDRO)

Healthcare Associated Infection · Multidrug Resistant Organisms

Enrolment: 83 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22929495 ↗2012Reported benefit

Ultraviolet C light for Acinetobacter baumannii wound infections in mice: potential use for battlefield wound decontamination?

MouseBurnContact / flameBALB/cFemalen = Burn model: 21 mice randomised to UVC-treated (n = 12) and…Topical illumination of the wound surface3.24 J/cm2 (20 min illumination) for skin abrasion; 2.59 J/…30 minutes after bacterial inoculation of the wound

Model: Partial-thickness dorsal skin abrasion and full-thickness burn (preheated brass block at approximately 95 degrees C for 7 s), each inoculated with a multidrug-resistant Acinetobacter baumannii clinical isolate carrying the luxCDABE operon

UVC reduced bacterial burden in treated wounds by approximately 10-fold compared with untreated infected controls (p = 0.004 abrasion, p = 0.019 burn). DNA lesions were induced in mouse skin immediately after 3.24 J/cm2 but were extensively repaired within 72 h.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

Loading the evidence…