Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome.
MouseRadiationC57BL/6Male and femalen = Groups of 30 mice for the amifostine and Neupogen survival…Antibiotics in drinking water (doxycycline partly in chow); amifostine subcutaneous; Neupogen subcutaneousEstimated intakes: neomycin 300 mg/kg/day, ciprofloxacin 10…Antibiotics days 4 to 30 after total body irradiation; amifostine 30 minutes be…
Model: Total body irradiation with caesium-137 at the LD50/30 to LD70/30 dose, dose rate 0.62 to 0.67 Gy per minute, delivered in the morning when mice were most radiosensitive
Ciprofloxacin, levofloxacin, doxycycline and neomycin all significantly increased mean survival time of decedent mice, while only ciprofloxacin (p = 0.061) and doxycycline plus neomycin (p = 0.005) showed some effect on 30-day survival. Amifostine 400 mg/kg and Neupogen 125 microgram/kg significant…
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