Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates postincisional pain by regulating macrophage polarization.
MouseWoundC57BL/6MaleLocal administration at the incisional site; a separate arm transplanted rosiglitazone-treated peritoneal macrophages into the incisional site
Model: Surgical incision producing postincisional pain
Local rosiglitazone significantly reduced heat and mechanical hypersensitivity and paw swelling, decreased M1 and increased M2 macrophage numbers at 24 h, raised M2-associated gene expression and lowered M1-associated gene expression. Transplantation of rosiglitazone-treated peritoneal macrophages…
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