The therapeutic efficacy of Ulinastatin for rats with smoking inhalation injury.
RatChemical/toxinSprague-DawleyMalen = 54 rats randomised equally to three groups (18 per group)
Model: Smoke inhalation acute lung injury
Ulinastatin attenuated lung histopathological change, improved pulmonary function, inhibited neutrophil accumulation, reduced pulmonary oedema and inflammatory response, prevented activation of NF-kappaB and p-JNK, and mitigated subsequent pulmonary fibrosis as shown by hydroxyproline content and c…
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