Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning.
RatChemical/toxinSprague-DawleyMaleIntraperitoneal injection6 mL/kg per 24 hAfter carbon monoxide poisoning
Model: Acute carbon monoxide poisoning causing brain injury
Hydrogen-rich saline improved cognitive deficits and reduced neuronal necrosis, apoptosis and autophagy. It decreased iron content in serum and brain and increased serum copper, suggesting reduced oxidative damage through effects on trace element metabolism.
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