Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril.
RatRadiationFemalen = N = 63 rats in the injury modelOral, in drinking waterDrinking water concentrations of 50, 150, 300 and 500 mg/L,…Started either immediately after irradiation or delayed until 2 weeks after exp…
Model: Single 10 Gy thorax-only irradiation of unanaesthetised rats, assessed at 2 months during development of radiation pneumonitis
Captopril at the vasoactive dose of 56 mg/kg/day mitigated radiation-induced pulmonary vascular injury, improving pulmonary vascular resistance, pulmonary arterial distensibility and distal vessel density, and remained effective when started 2 weeks after exposure. The lower 17 mg/kg/day dose was n…
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