17beta-estradiol protects 7-day old rats from acute brain injury and reduces the number of apoptotic cells.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMale and femalen = Study group n = 19, control group n = 21Intraperitoneal0.05 microgram per gram body weightThree doses before hypoxia at -64, -40 and -16 hours and one dose 3 hours after…
Model: Neonatal hypoxic-ischaemic brain injury by ligation of the left common carotid artery followed by 80 minutes of hypoxia in 8 per cent oxygen
Microscopic brain damage score was significantly lower with 17beta-estradiol (1.5 plus or minus 0.7 versus 2.8 plus or minus 0.8, p < 0.05) and affected hemisphere volumes were preserved. Apoptotic cell numbers were equal between hemispheres in the estradiol group, whereas controls had significantl…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.