Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy.
MouseChemical/toxinC57BL/6Male
Model: Aristolochic acid nephropathy with proximal tubular epithelial cell necrosis, transient acute kidney injury, mononuclear infiltration, tubular atrophy and interstitial fibrosis
Probenecid prevented the rise in plasma creatinine, prevented tubulointerstitial injury, reduced the extent and severity of ultrastructural lesions and significantly reduced proliferating cell nuclear antigen positive cell numbers and total aristolochic acid-DNA adducts compared with aristolochic a…
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