PebbleAtlas
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PRECLINICAL PUBLICATION · 2012

Treatment with low-dose methamphetamine improves behavioral and cognitive function after severe traumatic brain injury.

Rat / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 22847088 ↗2012Reported benefit

Treatment with low-dose methamphetamine improves behavioral and cognitive function after severe traumatic brain injury.

RatTBIFluid percussionWistarMale3 hours after injury

Model: Lateral fluid percussion injury producing severe traumatic brain injury

Low-dose methamphetamine significantly reduced neurological severity scores and foot faults, restored learning and memory to near normal, reduced hippocampal apoptotic cell death at 48 h and increased the number of immature neurons in the dentate gyrus compared with saline controls.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.