THERAPY DOSSIER · th-1289d49c364b

Methamphetamine, low dose

Drug · INHIBITOR of monoamine transporters (mec_id 1567, target CHEMBL2363064); direct_interaction and disease_efficacy true. ATC N06BA03; black_box_warning TRUE.

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: INHIBITOR of monoamine transporters (mec_id 1567, target CHEMBL2363064); direct_interaction and disease_efficacy true. ATC N06BA03; black_box_warning TRUE.
Target: CHEMBL2363064
Injury models: TBI
Reported indication: Not recorded
First approval: 1943
Development stage: Not recorded
ChEMBL record: CHEMBL1201201 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Metamfetamine; Desoxyn; NSC-25115; (S)-phenylmethylaminopropane; methamphetamine hydrochloride CHEMBL1200952; levmetamfetamine CHEMBL1927030
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01843205 ↗PHASE1completed

Buspirone as a Candidate Medication for Methamphetamine Abuse (methamphetamine administered as intervention)

Methamphetamine Dependence · Methamphetamine Abuse

Enrolment: 9 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22847088 ↗2012Reported benefit

Treatment with low-dose methamphetamine improves behavioral and cognitive function after severe traumatic brain injury.

RatTBIFluid percussionWistarMale3 hours after injury

Model: Lateral fluid percussion injury producing severe traumatic brain injury

Low-dose methamphetamine significantly reduced neurological severity scores and foot faults, restored learning and memory to near normal, reduced hippocampal apoptotic cell death at 48 h and increased the number of immature neurons in the dentate gyrus compared with saline controls.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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