Effect of local anesthetic on microorganisms in a murine model of surgical site infection.
MouseWoundFemaleSubcutaneous infiltration of the woundBefore surgical incision (pre-injury infiltration)
Model: Surgical wound infection model with Staphylococcus aureus and Escherichia coli inoculation of surgical wounds
Infiltration with saline, lidocaine or lidocaine mixed with bupivacaine did not produce significantly different bacterial presence or degree of inflammation once experimental condition of the bacterial inocula was controlled for; pre-incision local anaesthetic did not reduce bacterial growth or alt…
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