Is the sympathetic system involved in shock-induced gut and lung injury?
RatHaemorrhage/shockControlledSprague-DawleyMalen = n = 6 per group across 3 groups (unmanipulated control, LCH…Intraperitoneal10 mg/kgImmediately after resuscitation with shed blood, once mean arterial pressure wa…
Model: Unilateral lung contusion induced by percussive nail gun blast wave to the right axilla followed by 45 minutes of haemorrhagic shock (mean arterial pressure 30-35 mm Hg) and resuscitation with shed blood
LCHS increased gut permeability (plasma FD4 2.8 [0.4] vs 0.8 [0.2] microg/mL in controls) and lung injury score (8.5 [0.3] vs 4.0 [0.4]); propranolol reduced FD4 to 1.3 [0.3] microg/mL and lung injury score to 4.4 [1.3] (both p < 0.05 vs LCHS), lowered gut injury score to 1.5 [0.3] versus 2.4 [0.5]…
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