Still making the case against prehospital intubation: a rat hemorrhagic shock model.
RatHaemorrhage/shockControlledSprague-DawleyMalen = n = 10 intubated, n = 9 nose cone (19 rats total)Endotracheal intubation with mechanical ventilationIntubation and ventilation established before induction of haemorrhage
Model: Controlled haemorrhagic shock via carotid artery cannulation, exsanguination to a mean arterial pressure of 40 mm Hg with periodic bleeding to maintain MAP between 40 and 45 mm Hg
No survival advantage from intubation: time until death 85.5 minutes (intubated) versus 93.3 minutes (nose cone), p = 0.60. Intubated animals had higher lactic acid at 90 minutes (6.1 versus 3.5 mmol/L, p = 0.02) and 120 minutes (7.7 versus 2.6 mmol/L, p = 0.03), and worse base excess at 90 minutes…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.82. Machine-extracted fields require source verification.