THERAPY DOSSIER · th-3b40d7af4229

Endotracheal intubation with positive-pressure ventilation

Procedure · Supportive procedure (endotracheal intubation with positive-pressure ventilation); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Supportive procedure (endotracheal intubation with positive-pressure ventilation); not a ChEMBL entity
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22846936 ↗2012Mixed findings

Still making the case against prehospital intubation: a rat hemorrhagic shock model.

RatHaemorrhage/shockControlledSprague-DawleyMalen = n = 10 intubated, n = 9 nose cone (19 rats total)Endotracheal intubation with mechanical ventilationIntubation and ventilation established before induction of haemorrhage

Model: Controlled haemorrhagic shock via carotid artery cannulation, exsanguination to a mean arterial pressure of 40 mm Hg with periodic bleeding to maintain MAP between 40 and 45 mm Hg

No survival advantage from intubation: time until death 85.5 minutes (intubated) versus 93.3 minutes (nose cone), p = 0.60. Intubated animals had higher lactic acid at 90 minutes (6.1 versus 3.5 mmol/L, p = 0.02) and 120 minutes (7.7 versus 2.6 mmol/L, p = 0.03), and worse base excess at 90 minutes…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.82. Machine-extracted fields require source verification.

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