The histopathological comparison of L-carnitine with amifostine for protective efficacy on radiation-induced acute small intestinal toxicity.
RatRadiationWistar albinon = 30 rats total: control n = 6, irradiation alone n = 8, amif…L-carnitine 300 mg/kg; amifostine 200 mg/kg30 minutes before irradiation (pre-treatment)
Model: Radiation-induced acute small intestinal injury after a single 20 Gy dose to the total abdomen
Amifostine reduced radiation-induced acute degenerative damage (P = 0.009) and lowered the overall damage score (P = 0.009) versus irradiation alone, whereas L-carnitine produced no significant difference in degenerative damage or overall score. Vascular damage was significantly reduced by both ami…
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