Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries.
MouseChemical/toxinfemalepretreatment before exposure to the hepatotoxic compound
Model: drug-induced and chemical-induced acute liver injury produced by acetaminophen, bromobenzene, diclofenac or thioacetamide
Pretreatment with ethinylestradiol, tamoxifen and raloxifene reduced liver injury caused by several hepatotoxicants in female mice, whereas an oestrogen receptor antagonist gave no protection. Protection by tamoxifen and the associated rise in Mmd2 mRNA were lost in oestrogen receptor alpha knockou…
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