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PRECLINICAL PUBLICATION · 2012

Ameliorative effects of resveratrol on acute ovarian toxicity induced by total body irradiation in young adult rats.

Rat / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 22840937 ↗2012Reported benefit

Ameliorative effects of resveratrol on acute ovarian toxicity induced by total body irradiation in young adult rats.

RatRadiationfemalen = 30 female rats randomised to four groups: control n = 7, 10…intraperitoneal10 mg/kg (low dose) or 100 mg/kg (high dose)single dose given 24 hours before total body irradiation

Model: acute ovarian toxicity induced by total body irradiation

Both resveratrol doses gave significantly higher total follicle counts than the irradiated control group (P < 0.01), with the low dose preserving more primary follicles than the high dose. Glutathione peroxidase and catalase activities were significantly raised in resveratrol-treated animals. Fibro…

Extraction: extract · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.