The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans.
MixedTBIUnspecified
Model: mouse model of neurotrauma with assessment of cerebrovascular permeability and neurological function; human neurotrauma cerebrospinal fluid and brain tissue
Tissue plasminogen activator potentiated neurovascular damage dose-dependently, and administration of plasminogen activator inhibitor-1 unexpectedly increased cerebrovascular permeability through formation of tissue plasminogen activator:plasminogen activator inhibitor-1 complexes that bind low-den…
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