THERAPY DOSSIER · th-ebd219e68e7c

matrix metalloproteinase-3 inhibitor (with tissue plasminogen activator and plasminogen activator inhibitor-1 administered as mechanistic interventions)

Drug · Pharmacological class rather than a named molecule; no confident single ChEMBL entity. ClinicalTrials.gov returned no MMP-3 selective inhibitor trial; registered MMP inhibitor programmes target other family members (e.g. prinomastat, andecaliximab/MMP-9, doxycycline).

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Pharmacological class rather than a named molecule; no confident single ChEMBL entity. ClinicalTrials.gov returned no MMP-3 selective inhibitor trial; registered MMP inhibitor programmes target other family members (e.g. prinomastat, andecaliximab/MMP-9, doxycycline).
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: MMP-3 inhibitor; Stromelysin-1 inhibitor
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22822039 ↗2012Reported benefit

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans.

MixedTBIUnspecified

Model: mouse model of neurotrauma with assessment of cerebrovascular permeability and neurological function; human neurotrauma cerebrospinal fluid and brain tissue

Tissue plasminogen activator potentiated neurovascular damage dose-dependently, and administration of plasminogen activator inhibitor-1 unexpectedly increased cerebrovascular permeability through formation of tissue plasminogen activator:plasminogen activator inhibitor-1 complexes that bind low-den…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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