Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats.
RatSpinal cord injuryHemisection / partialSprague-DawleyFemalen = 56 female rats in total; spinal cord injury n=15, NAC n=13,…Continuous intrathecal infusion via subcutaneously implanted Alzet 2002 osmotic minipump with catheter tip at the L3 to L4 dorsal root gangliaNAC 2.4 mg/day (pump solution 200 mg/ml) and ALC 0.9 mg/day…Started immediately after spinal cord hemisection
Model: L5 spinal cord hemisection, transection of the lateral funiculus and adjacent grey matter after lumbar laminectomy, with tibial motoneurons pre-labelled with Fast Blue one week earlier
Hemisection reduced tibial motoneuron survival to 62% of control. NAC increased survival to 78% and ALC to 80%, rescuing approximately half of the motoneurons destined to die. NAC restored MAP2 and synaptophysin immunoreactivity to 89% and 107% of control and neurofilament staining to 104%, while A…
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