Transplantation of bone marrow cells decreases tumor necrosis factor-alpha production and blood-brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease.
MouseChemical/toxinC57Bl/610(7) bone marrow mononuclear cells
Model: Acetaminophen-induced acute liver failure, produced by an alcoholic diet followed by fasting and injection of acetaminophen
BMC transplantation significantly reduced acetaminophen-induced mortality and partially protected against blood-brain barrier disruption, and decreased serum TNF-alpha in association with an early rise in splenic and bone marrow interleukin-10 mRNA. However, there were no significant differences in…
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