THERAPY DOSSIER · th-7235fe471296

Bone marrow mononuclear cells (BMC) obtained from enhanced green fluorescent protein transgenic mice

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02022514 ↗PHASE2/PHASE3completed

Intracoronary Infusion of Autologous Bone Marrow Mononuclear Cells in Chronic Coronary Occlusion

Coronary Atherosclerosis and Other Heart Disease

Enrolment: 28 · Results not recorded

NCT02171949 ↗PHASE2unknown

Multiple Infusions of Mononuclear Bone Marrow Cells in Chronic Liver Diseases

Chronic Hepatitis · Hepatic Cirrhosis

Enrolment: 30 · Results not recorded

NCT03943940 ↗PHASE1/PHASE2unknown

BM-MNC and UC-MSC Infusion for Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

Enrolment: 60 · Results not recorded

NCT03080571 ↗PHASE1completed

Intraarterial Bone Marrow Derived Mononuclear Cells in Subacute Ischaemic Stroke

Ischemic Stroke · MCA Infarction

Enrolment: 20 · Results not recorded

NCT02286011 ↗PHASE1unknown

Intramuscular Infusion of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22809224 ↗2012Mixed findings

Transplantation of bone marrow cells decreases tumor necrosis factor-alpha production and blood-brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease.

MouseChemical/toxinC57Bl/610(7) bone marrow mononuclear cells

Model: Acetaminophen-induced acute liver failure, produced by an alcoholic diet followed by fasting and injection of acetaminophen

BMC transplantation significantly reduced acetaminophen-induced mortality and partially protected against blood-brain barrier disruption, and decreased serum TNF-alpha in association with an early rise in splenic and bone marrow interleukin-10 mRNA. However, there were no significant differences in…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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