Effect of recombinant human platelet-derived growth factor-BB-coated sutures on Achilles tendon healing in a rat model: A histological and biomechanical study.
RatWoundSprague-Dawleyn = 48 rats, n = 12 per group; biomechanics analysed n = 7 (gro…Local delivery from the coated suture implanted at the tendon repair siteCoating solutions of 0 (20 mM sodium acetate vehicle), 0.3,…At the time of repair, immediately after transection
Model: Acute Achilles tendon transection proximal to the calcaneal insertion, immediately repaired with sutures
Ultimate tensile strength increased significantly in the two highest dose groups (1.9 plus or minus 0.5 and 2.1 plus or minus 0.5 MPa) versus control (1.0 plus or minus 0.2 MPa), and modulus increased in the highest dose group (7.2 plus or minus 3.8 versus 3.5 plus or minus 0.9 MPa, p = 0.031). Max…
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