PRECLINICAL PUBLICATION · 2012

Localized and sustained delivery of fibroblast growth factor-2 from a nanoparticle-hydrogel composite for treatment of spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Fibroblast growth factor-2 (FGF2) encapsulated in poly(lactide-co-glycolide) nanoparticles embedded in a hyaluronan and methylcellulose (HAMC) hydrogel

PMID 22796886 ↗2012Reported benefit

Localized and sustained delivery of fibroblast growth factor-2 from a nanoparticle-hydrogel composite for treatment of spinal cord injury.

RatSpinal cord injuryCompressionSprague-DawleyFemaleIntrathecal injection of the HAMC/PLGA/FGF2 compositeImmediately after clip compression injury

Model: 26 g clip compression spinal cord injury

Sustained localised delivery of FGF2 from the composite increased dorsal horn blood vessel density 28 days post-injury without producing the proliferative lesions previously reported for minipump and catheter delivery of FGF2.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.