Beneficial Effects of Ocimum gratissimum Aqueous Extract on Rats with CCl(4)-Induced Acute Liver Injury.
RatChemical/toxinWistarMalen = 32 rats in total, 8 per group across 4 groupsOral0.2 mg/kg body weightConcurrent with CCl4 dosing across the 12-week period
Model: Carbon tetrachloride (CCl4) induced hepatic injury, intraperitoneal CCl4 twice weekly for 12 weeks
OGAE significantly increased serum catalase and DPPH scavenging and significantly reduced hepatic HSP70, iNOS, MMP-9/MMP-2 ratio, uPA, phosphorylated ERK and phosphorylated p65 compared with CCl4 alone, with effects comparable to silymarin. No numerical effect sizes were reported.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.