THERAPY DOSSIER · th-4326a73271e2

Ocimum gratissimum aqueous leaf extract (OGAE)

Nutraceutical · Botanical extract (Ocimum gratissimum aqueous leaf extract); not a ChEMBL entity; no matching trial identified

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Botanical extract (Ocimum gratissimum aqueous leaf extract); not a ChEMBL entity; no matching trial identified
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22792126 ↗2012Reported benefit

Beneficial Effects of Ocimum gratissimum Aqueous Extract on Rats with CCl(4)-Induced Acute Liver Injury.

RatChemical/toxinWistarMalen = 32 rats in total, 8 per group across 4 groupsOral0.2 mg/kg body weightConcurrent with CCl4 dosing across the 12-week period

Model: Carbon tetrachloride (CCl4) induced hepatic injury, intraperitoneal CCl4 twice weekly for 12 weeks

OGAE significantly increased serum catalase and DPPH scavenging and significantly reduced hepatic HSP70, iNOS, MMP-9/MMP-2 ratio, uPA, phosphorylated ERK and phosphorylated p65 compared with CCl4 alone, with effects comparable to silymarin. No numerical effect sizes were reported.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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