Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion.
RatSpinal cord injuryContusionSprague-DawleyMalen = n = 4 to 6 rats per time point for immunoblot plus four lam…Intraperitoneal injection1 mg/kgBeginning 3 h post-injury
Model: Moderate contusive spinal cord injury at T8, 10 g weight dropped 25 mm onto an impounder on the exposed dura
CR8 reduced lesion volume at 4 months (40.8 plus or minus 3.6 per cent of total volume versus 52.4 plus or minus 5.0 per cent in vehicle) and attenuated sustained cell cycle protein, GFAP, Iba-1, OX42 and p22PHOX immunoreactivity. BBB scores improved significantly from week 2 and Combined Behaviour…
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