THERAPY DOSSIER · th-1c315d9af3d7

CR8, a second-generation roscovitine analogue and selective cyclin-dependent kinase inhibitor

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03774446 ↗PHASE2recruiting

Phase 2 Study of Seliciclib (R-roscovitine) for Cushing Disease

Cushing Disease

Enrolment: 13 · Results not recorded

NCT02649751 ↗PHASE2terminated

(R)-Roscovitine in Adults With Cystic Fibrosis (ROSCO-CF)

Cystic Fibrosis

Enrolment: 49 · Results not recorded

NCT02160730 ↗PHASE2terminated

Pituitary Cushing Disease Treated With Selective CDK Inhibitor R-roscovitine

Cushings Disease

Enrolment: 4 · Results not recorded

NCT00999401 ↗PHASE1completed

Phase I Study of Oral Sapacitabine and Oral Seliciclib in Advanced Solid Tumors

Advanced Solid Tumors

Enrolment: 103 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22784881 ↗2012Reported benefit

Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion.

RatSpinal cord injuryContusionSprague-DawleyMalen = n = 4 to 6 rats per time point for immunoblot plus four lam…Intraperitoneal injection1 mg/kgBeginning 3 h post-injury

Model: Moderate contusive spinal cord injury at T8, 10 g weight dropped 25 mm onto an impounder on the exposed dura

CR8 reduced lesion volume at 4 months (40.8 plus or minus 3.6 per cent of total volume versus 52.4 plus or minus 5.0 per cent in vehicle) and attenuated sustained cell cycle protein, GFAP, Iba-1, OX42 and p22PHOX immunoreactivity. BBB scores improved significantly from week 2 and Combined Behaviour…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

Loading the evidence…