Corticosteroid treatment inhibits airway hyperresponsiveness and lung injury in a murine model of chemical-induced airway inflammation.
MouseChemical/toxinC57BL/6Female1, 2 or 6 h after melphalan exposure
Model: Airway exposure to the nitrogen mustard analogue melphalan
Melphalan increased central and peripheral airway hyperresponsiveness and caused macrophage and neutrophil dominated inflammation. Dexamethasone given 1 h after exposure protected better than dosing at 2 or 6 h, and treatment reduced collagen deposition at 14 days.
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