A study of the potential neuroprotective effect of riluzole on locomotor networks of the neonatal rat spinal cord in vitro damaged by excitotoxicity.
RatSpinal cord injuryUnspecifiedWistarBath application to the isolated spinal cord preparation in vitro5 micromolarApplied continuously after kainate, applied for 3 h coinciding with peak kainat…
Model: In vitro excitotoxic injury of the isolated neonatal spinal cord by transient (1 h) application of kainate 0.05 to 0.1 mM
Riluzole partially reduced pyknotic cell numbers in grey matter when applied continuously, but motoneurons remained vulnerable and fictive locomotion did not recover under any protocol, including 3 h application or co-application with kainate.
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