Beta-adrenergic receptor inhibition affects cerebral glucose metabolism, motor performance, and inflammatory response after traumatic brain injury.
MouseTBIUnspecifiedC57BL/6, with beta1/beta2-adrenergic receptor knockout (BARKO) miceMaleTail vein injection4 mg/kgAfter traumatic brain injury
Model: Traumatic brain injury in mice, with sham injury controls
Cerebral glucose metabolism fell after injury (mean SUV 1.63 versus sham 1.97, p less than 0.01) and propranolol attenuated this reduction (1.89 versus 1.63, p less than 0.01). Propranolol and receptor knockout both reduced motor deficits at 24 h, with rotarod 44 versus 23 seconds and rearing 338 v…
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