Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMaleIntraperitoneal injection0.6 mmol/L hydrogen-rich saline, 0.5 mL/kg/dayThree days of pre-treatment before reperfusion combined with immediate administ…
Model: 45 min occlusion of the right lung root followed by 120 min reperfusion
Hydrogen-rich saline preserved pulmonary artery vasoactivity, reduced pulmonary oedema, lowered lung malondialdehyde and 8-OHdG, reduced epithelial cell apoptosis and lowered white cell count, CRP, ALT and total bilirubin.
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