Prophylactic 0.9% saline hydration inhibited high-dose gadodiamide-induced nephropathy in rats.
RatChemical/toxinSprague-Dawleyn = 12 rats randomised into two groups of sixIntraperitoneal bolus infusion0.9 per cent saline 4 mL/kg per bolusStarting 12 h before and continuing for 12 h after the gadodiamide injection
Model: High-dose gadodiamide (5 mmol/kg) induced acute kidney injury
Creatinine clearance fell by 15 per cent in hydrated rats versus 39 per cent in controls (p = 0.02), and proximal tubular vacuolisation (p = 0.01) and epithelial sloughing (p = 0.02) were significantly less frequent with hydration.
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