THERAPY DOSSIER · th-1e13b59e05e8

Prophylactic 0.9 per cent saline hydration

Procedure · Procedure (prophylactic saline hydration); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Procedure (prophylactic saline hydration); not a ChEMBL entity
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02872155 ↗PHASE3completed

Oral Versus Intravenous (Saline) Hydration to Prevent Contrast-induced Nephropathy

Contrast-induced Nephropathy

Enrolment: 264 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22736251 ↗2012Reported benefit

Prophylactic 0.9% saline hydration inhibited high-dose gadodiamide-induced nephropathy in rats.

RatChemical/toxinSprague-Dawleyn = 12 rats randomised into two groups of sixIntraperitoneal bolus infusion0.9 per cent saline 4 mL/kg per bolusStarting 12 h before and continuing for 12 h after the gadodiamide injection

Model: High-dose gadodiamide (5 mmol/kg) induced acute kidney injury

Creatinine clearance fell by 15 per cent in hydrated rats versus 39 per cent in controls (p = 0.02), and proximal tubular vacuolisation (p = 0.01) and epithelial sloughing (p = 0.02) were significantly less frequent with hydration.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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