Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13.
RatHaemorrhage/shockControlledSprague-DawleyMalen = n = 5 per group for sham, shock and shock plus hypertonic s…Nebulised inhalation2 mL of 7.5 per cent hypertonic saline per dose, delivered…First dose at the end of the shock period, at the onset of resuscitation
Model: 3 cm midline laparotomy tissue injury plus controlled haemorrhagic shock (40 per cent blood volume removed, mean arterial pressure 30 mm Hg for 45 min) followed by resuscitation
Nebulised hypertonic saline reduced lavage protein from 1.56 plus or minus 0.2 to 0.95 plus or minus 0.3 mg/mL, CINC-1 from 5999 plus or minus 1267 to 3342 plus or minus 859 pg/mL and MMP-13 from 1513 plus or minus 337 to 230 plus or minus 19 pg/mL. Lung myeloperoxidase fell non-significantly. Pret…
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