THERAPY DOSSIER · th-e12c5fd638d2

Nebulised 7.5 per cent hypertonic saline

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06267118 ↗PHASE3recruiting

Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis in Children

Acute Bronchiolitis Due to Respiratory Syncytial Virus

Enrolment: 60 · Results not recorded

NCT03323567 ↗EARLY_PHASE1completed

Collagen, Lidocaine and Hypertonic Saline Intramuscular Injections in Myofascial Pain

Temporomandibular Disorder

Enrolment: 43 · Results not recorded

NCT02303808 ↗NAcompleted

Positive Expiratory Pressure Device During Inhalation of Hypertonic Saline in Cystic Fibrosis

Cystic Fibrosis

Enrolment: 20 · Results not recorded

NCT02458300 ↗NAcompleted

Chest Physiotherapy With Nebulisation of Hypertonic Saline in Infants With Acute Bronchiolitis

Bronchiolitis

Enrolment: 77 · Results not recorded

NCT07699302 ↗NAnot yet recruiting

Non-ciliary Mechanisms of Airway Clearance in Muco-obstructive Lung Disease (HS pretreatment)

Primary Ciliary Dyskinesia

Enrolment: 8 · Results not recorded

NCT00345215 ↗NAcompleted

High and Low Sodium Intake on Aquaporin-2 After Hypertonic Saline Infusion in Healthy Humans

Healthy Humans

Enrolment: 26 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22732292 ↗2012Reported benefit

Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13.

RatHaemorrhage/shockControlledSprague-DawleyMalen = n = 5 per group for sham, shock and shock plus hypertonic s…Nebulised inhalation2 mL of 7.5 per cent hypertonic saline per dose, delivered…First dose at the end of the shock period, at the onset of resuscitation

Model: 3 cm midline laparotomy tissue injury plus controlled haemorrhagic shock (40 per cent blood volume removed, mean arterial pressure 30 mm Hg for 45 min) followed by resuscitation

Nebulised hypertonic saline reduced lavage protein from 1.56 plus or minus 0.2 to 0.95 plus or minus 0.3 mg/mL, CINC-1 from 5999 plus or minus 1267 to 3342 plus or minus 859 pg/mL and MMP-13 from 1513 plus or minus 337 to 230 plus or minus 19 pg/mL. Lung myeloperoxidase fell non-significantly. Pret…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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