TNFR1-dependent pulmonary apoptosis during ischemic acute kidney injury.
MouseIschaemia-reperfusionRenalC57BL/6, with TNFR1 knockout miceMale
Model: Murine kidney ischaemia-reperfusion injury causing ischaemic acute kidney injury with remote lung injury
Disruption of TNF-alpha signalling with etanercept implicated circulating TNF-alpha as a key mediator of pulmonary apoptosis and lung microvascular barrier dysfunction during ischaemic acute kidney injury, while inhibition of NF-kappaB produced a proapoptotic phenotype and barrier leak independent…
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