Lithium treatment reduces brain injury induced by focal ischemia with partial reperfusion and the protective mechanisms dispute the importance of akt activity.

Lithium treatment reduces brain injury induced by focal ischemia with partial reperfusion and the protective mechanisms dispute the importance of akt activity.

Model: Permanent distal middle cerebral artery occlusion combined with transient bilateral common carotid artery occlusion, modelling stroke with partial reperfusion

A bolus of lithium at stroke onset robustly reduced infarct size at 48 h and inhibited cell death in the ischaemic penumbra but not the core at 24 h, without altering Akt activity, phosphorylated GSK3beta or beta-catenin degradation.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.