Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia.
RatOtherSprague-DawleyMaleOral0.05 or 0.1 mg/kg body weightGiven daily during the 5 days of hypobaric hypoxia exposure
Model: Simulated hypobaric hypoxia at 6,000 m in an animal decompression chamber for 5 days
Huperzine A at 0.1 mg/kg restored spatial memory, with decreased escape latency and path length and increased platform crossings and quadrant time, and significantly reduced hippocampal oxidative stress and pro-apoptotic protein expression.
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